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8. Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells. J. Nat. Prod. 2020, 83, 1829-1845.  David A. Russel, Hannah R. Bridges, Ricardo Serelli, Sarah L. Kidd, Natalia Mateu, Thomas J. Osberger, Hannah F. Sore, Judy Hirst, and David R. Spring. 

7. C(sp3)-H  Arylation to Construct All-syn Cyclobutane-Based Heterobicyclic Systems: A Novel Fragment Collection.   Chem Commun. 2020, 56, 7423-7426. Thomas J. Osberger, Sarah L. Kidd, Thomas A. King, and David R. Spring.


Check out the discussion of this and other publications on Practical Fragments!

6. Fsp3-Rich and Diverse Fragments Inspired by Natural Products As a Collection to Enhance Fragment-Based Drug Discovery. Chem. Commun. 2020, 56, 2280. Abigail R. Hanby, Nikolaj S. Troelsen, Thomas J. Osberger, Sarah L. Kidd, Kim T. Mortensen, and David R. Spring. 

5. Strategies for the Diversity-Oriented Synthesis of MacrocyclesChem. Rev. 2019, 119, 17, 10288-10317. Kim T. Mortensen, Thomas J. Osberger, Thomas A. King, Hannah F. Sore, and David R. Spring. 


4. Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment CollectionsFront. Chem., 2018, 6:460. doi: 10.3389/fchem.2018.00460

Sarah L. Kidd, Thomas J. Osberger, Natalia Mateu, Hannah F. Sore, and David R. Spring

Check out the discussion of 3D fragments featuring this and other publications in Practical Fragments!

3. The Application of Diversity-Oriented Synthesis in Chemical Biology. In Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology, Ed. A. Nelson. and N. Westwood. RSC Press, 2018, p 8-44. 

N. Mateu, S. L. Kidd, T. J. Osberger, H. Stewart, S. Bartlett, W. R. J. D. Galloway, A. J. P. North, H. F. Sore, and D. R. Spring

2. Oxidative Diversification of Amino Acids and Peptides Enabled by Small-Molecule Iron CatalysisNature, 2016, 537, 214-219.

Thomas J. Osberger*, Donald C. Rogness*, Jeffrey S. Kohrt§, Antonia F. Stepan§, and M. Christina White. *Equal contributors. §Pfizer collaborators.

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Check out the highlights of this work in Nature ChemistryC&E News and In the Pipeline!

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